(D-Arg2,Lys4)-Dermorphin (1-4) amide

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

DALDA 是一种强效和高选择性 μ-opioid receptor 激动剂，其 Ki 为 1.69 nM。 DALDA 具有抗痛和呼吸作用。

DALDA is a potent and highly selective μ-opioid receptor agonist with a Ki of 1.69 nM. DALDA shows antinociceptive and respiratory effects.

DALDA (0-7 nmol/rat; i.t.; once) 在大鼠中表现出抗痛和呼吸作用。DALDA (0.1 and 1.0 μg/side; ICV; once) 在大鼠中产生双相效应，初始抑制，中间显著抑制，接着是水平运动、饲养和刻板印象次数的激活。Animal Model:Male Sprague-Dawley rats (300–350 g)Dosage:0.24, 0.7 and 7 nmol/rat Administration:Intrathecal injection, once Result:Showed antinociceptive effects with an ED50 of 237 pmol/rat in the rat tail-flick test. Inhibited the uptake of NE in spinal cord synaptosomes in a dose-dependent manner. Had no effect on 5-HT uptake. Produced depression in minute ventilation.Animal Model:Male Long-Evans rats, weighing 200-225 g Dosage:0, 0.1 and 1.0 μg/side, 0.5 μL Administration:Lateral cerebral ventricle injection, once Result:Elicited a significant biphasic effect with an initial suppression, an intermediate marked inhibition, followed by significant activation for horizontal movement time, rearing time, and stereotypy time.

DALDA 在生理 pH 值下携带净正电荷 (3+)，因此是亲水的，比吗啡更极性。

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Others

Other Targets

μ Opioid Receptor/MOR: 1.69 nM (Ki), κ Opioid Receptor/KOR: 4230 nM (Ki), δ Opioid Receptor/DOR: 19200 nM (Ki)

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118476-85-0

611.75

C30H45N9O5

>98% (HPLC)

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(-20℃)

With Ice Pack

≥ 2 years